![]() They’ve also done isotope analysis on their bones, which reveals these people had a diet high in protein, mostly from fish. Scientists working on the site have sequenced the DNA for several of the individuals-that’s how they figured out that two of the crania were female. One of the crania still had some brain residues clinging to the inside, which suggests the brain was in there during secondary burial. In one case, the secondary burial came very quickly. After that, someone removed their heads, took off their lower jaws, and placed them in the middle of the lake-sometimes on a stake. All the people at Kanaljorden had been exposed or buried for a period of time, likely until most of their flesh was gone. In fact, they arrived on the artificial island as part of a “secondary burial” ritual, a term for what happens when bodies are moved from one burial site to another. ![]() ![]() Their bodies were given special treatment after death. There’s another key indicator that these people may have been special members of the community rather than defeated bad guys put on display. One possible explanation for this is that women occupied different positions from men in battle and thus got hit in slightly different spots. Gummesson and her colleagues note that the women had injuries mostly on the sides of their heads, while the men had injuries on the top. While this doesn’t rule out the idea that these were enemies, it seems more likely they were members of the community who fought battles and survived. Most of these men and women had recovered from their wounds at the time they died. Though a number of crania at the site showed trauma from weapons, there’s evidence that these injuries had healed over time. Forensic analysis reveals a much more complicated story. Advertisementįirst, it’s important to dispel the myth that this site was for displaying the remains of enemies, killed violently and staked. And their reasons are not quite what you might imagine. Though we’ve seen lots of heads on stakes in Game of Thrones and various movies, Kanaljorden is the first time anyone has found evidence in real life that Stone Age people in this area were mounting heads on stakes. In a recent article for Antiquity, Stockholm University archaeologist Sara Gummesson and her colleagues explain what the evidence reveals about how this ritual site was used. Now dubbed “Kanaljorden,” the archaeological site has finally begun to yield some secrets about the people who created it. A pile of rocks rose above the water, covered in weapons, wooden structures, and the grisly remains of fearsome animals-as well as the skulls of some carefully chosen people. ![]() Thousands of years ago, this semi-submerged burial ground must have been an imposing sight for the small settlements located nearby. Two of the human skulls were mounted on pointed stakes. They also found the bones of bears, deer, boar, and a badger. For roughly 7,500 years, a shallow, swampy lake in the area had hidden a pile of stones that contained the skeletal remains of at least 10 people and weapons made of stone and antler. In east-central Sweden, workers demolishing a railway that crossed the Motala Ström River discovered something bizarre.
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![]() You can also protect notes with a password. It has various other useful features such as a Recents List and the ability to change fonts and text color. INotePad for Mac is a slicker, more powerful solution which allows you to cut and paste snippets and drag text from other applications into it. NotePadĪlthough NotePad isn’t free (not to be confused with NotePad for Mac below or the original NotePad on Windows), NotePad TXT Editor is just t $1.99 from the app store and is suitable for simple documents or notes without any formatting. The most unique thing about Tincta is it’s terms and conditions which actually request you to take steps to reduce global warming in order to use it! 4. Tincta works natively on M1 and M2 Macs so performance is optimized for those Macs. Excellent for taking notes or making lists, it can also be used for basic HTML coding. Tincta is a very simple text editor for Mac. There is an advanced version of BBEdit which offers more coding tools although this isn’t free and requires you to purchase a license starting at $49.99. It can be used for checking prefs, html or xml files of all types.īBEdit works natively on M1 and M2 Macs so performance is optimized for those Macs. ![]() BBEditīBEdit (formerly known as TextWrangler) is a very popular text editing tool and an excellent alternative to Notepad on Mac.īBEdit is an advanced HTML editor although can be used for basic note taking. To open TextEdit in HTML mode, simply select “Ignore rich text commands in HTML files” from the File Menu.Īlternatively, to open in Plain Text by default just ensure that “Plain Text” is selected from the Format menu. TextEdit is useful mainly as a simple text editing tool but you can even edit HTML in it. To find it, simply search for TextEdit in Spotlight or CMD click on your desktop and select “TextEdit”. TextEdit is the Mac equivalent of NotePad and is free with all versions of macOS. It’s free with any version of macOS but is very basic and there are other free and paid options out there with a few more advanced features. The most obvious choice for those looking for a replacement for NotePad on Mac is TextEdit which is the default text editing app for Mac. Here then is our list of the best alternatives to NotePad for Mac in order of ranking. Top Microsoft Publisher For Mac Replacements.Best Word For Mac Alternatives & How To Get It For Free.How To Get Microsoft Office For Mac Free.The apps here are in the order of free to paid options – there’s really no need to pay for a simple text editing app on Mac unless you need special formatting features or if you are programmer writing HTML.Īll of them work on the latest M1 and M2 Macs too thanks to Rosetta which translates Intel only apps to work on Apple Silicon Macs. We’ve tried to focus on basic NotePad text editors here and avoided dedicated HTML editors for programmers such as NotePad++. If you don’t want to run NotePad on your Mac however, here we’ve looked at the best NotePad for Mac alternatives. Parallels also works on the latest Apple Silicon M1 and M2 chip Macs as well. The best way to run Windows on a Mac is using Parallels which allows you to run macOS and Windows side-by-side so you can switch between then whenever you want. NotePad for Mac does not exist but if you’ve just switched to Mac from PC we’ve looked at the best NotePad alternatives for Mac.įirstly, although Windows NotePad doesn’t exist for Mac, you can install NotePad on a Mac by running Windows on a Mac. ![]() ![]() Because it gets annoying when I only want to upgrade certain locos or trucks, and have to find each one I want all around the map. Voxels are small geometric primitives used to construct larger worlds. This would simply just be a seperate tab where you can view your vehicles all in one, check their profitability, etc. Find game assets tagged Voxel like Voxel environment assets : Desert town, Voxel Robot assets for free, 10+ Voxel Spaceships assets for free, Voxel Ancient Environment assets for free, Voxel Plane assets on itch.io, the indie game hosting marketplace. So a modpack for some of the other locos you were possibly going to choose would be nice!ĥ. Like the Class O, the heck is that? Just a generic black switcher in my book. It is these lush graphics that make decisions to carve up the landscape with trains actually have some emotional weight. To be honest, I was a bit dissapointed that some of the locos were so out there. Voxel Tycoon is currently in pre-alpha stage over at itch.io and as is often the case with games on itch.io, it instantly grabs attention through low-poly, beautiful graphics. If you could create a modpack for the other locomotive candidates you were going to select. Voxel Tycoon comes to early access release on Itch.io and now you can procedurally generate your own voxel based tycoon business empire. The ability to possibly only install mods into certain maps you created(?) I doubt this is possible, but I dont know! - you're the DEV's!Ĥ. It is also a bit annoying to have to demolish a station, build an entire new one, and then re - route ALL trains that go to that station! PLEASE ADD THIS!!!!!!!ģ. Find game assets tagged Tycoon and Voxel like Town Tycoon pack, Supermarket Voxel 3D Asset Pack, Voxel Studio, Voxel - Record Stand for Shop on itch. The Ability to add platforms and extend the width of an existing station. ![]() This is an absolute MUST!!! It is very annoying to have to build tunnels or bridges (Which are really expensive) Over each other.Ģ. You can purchase the game on Steam, itch.io and Xbox Store. Here are my suggestions (Not many, surprising!)ġ. You can play Train Station Simulator on Linux, PC and Xbox One. Support us View supporter archive More News Atari will hold RollerCoaster Tycoon rights for another decade Ups and downs. License: - you can use the models in private or commercial projects. all models come in the following files. What this pack contains: - 14 different characters, models are not animated. Heyo, This game is absolutely FANTASTIC!!! A tycoon strategy game about mining, transportation, and building factories in an unlimited voxel landscapes. All these voxel models are made in MagicaVoxel. If you have competition, lower prices, increase marketing, and improve your branch's stats when you build them. Closer you can get to per-capita (or lower) the better! This should greatly increase your sales volume. So if you're aiming for volume, you need to open up more branches, and you need to lower your prices as much as possible. You'll probably find 3000 models a month is pretty low. Simply go to Sales Book -> Reports -> Generate Reports -> Then create a report showing top vehicles, etc. By today standards that's a good production run. So, 3000 per month per model? That's 36,000 vehicles a year which is not too bad. So in 1920 roughly 2,000,000 people should be in the market for vehicles throughout the year world wide, and throughout all income levels. The population pools are modeled after historical data. I am interested in finding out if my numbers for car sales are in line with what others are experiencing. Each game I start is typically in London/NY/Chicago.Car sales stay around 3000 models once the games ages into the 20s. Originally posted by jdmgr74:I have been playing in Normal mode for about two weeks. Is this normal, what should be the expectations? What I am seeing is owning 45% of the company and offering more than double the stock value is refused. My main question is about stocks and takeovers. I am, of course am making the major money in the market through stocks. Once the radio comes out in the 20s, i tend to use about 5k on cities above 750k pop just in band marketing. If a car is not producing the number i will advertise it in papers. ![]() What advertising materials do you use? I spend about 1000 on each for brand marketing. But playing straight with branches, factories what should expect in the way of sales numbers. I played with the contract system for minute which does stretch models out without changes for 10+ years. So I basically have sedan, full size sedan, truck. ![]() I create new body styles only when the demand shows above average interest. I change models (1910 sedan, 1915 sedan new body style, new mechanicals if available, same for 1920, 1925 etc.) every five years through the "new model year" system. I am micro manage every three months the assembly lines to ensure build/sales rates are inline with each other. ![]() I have been playing in Normal mode for about two weeks. It has a robust visualization mechanism of any type of data, as well as a complete handling of time sequences of data. It was funded by CardioSense3D project and aims at providing the researcher with a set of tools for pre-processing data and to visualize results of cardiac simulations. MUSIC is a software developed in collaboration with the IHU LIRYC in order to propose functionalities dedicated to cardiac interventional planning and guidance, based on the medInria software platform.ĬardioViz3D targets research in cardiac imaging. MUSIC: Multi-modality Platform for Specific Imaging in Cardiology medInria is available for Microsoft Windows, Linux Fedora / Ubuntu, Mac OS X, and is fully multi-threaded. Efforts have been made to simplify the user interface, while keeping high-level algorithms. medInria aims at providing to clinicians state-of-the-art algorithms dedicated to medical image processing and visualization. MedInria is a free medical imaging software developed at Inria. It can also simulate realistic variation of intensity. At its core, it implements a biophysical model of brain deformation with atrophy in Alzheimer’s disease. The tool was developed to generate synthetic time-series structural MRIs with specified ground truth atrophy. For more details about the method, the model, and the performance, please refer to the paper 3D Consistent & Robust Segmentation of Cardiac Images by Deep Learning with Spatial (available here) is a C++ based simulator tool that can simulate specified volume changes in different parts of the image. The code of the method and the instructions for use are also available on this GitHub page. A package containing the code of the method, the pre-trained weights of the model, and the instructions for use can be downloaded here. Using deep learning with the spatial propagation of the segmentation, the method is both consistent and robust. For more details about the method, the model, and the performance, please refer to the paper Explainable Cardiac Pathology Classification on Cine MRI with Motion Characterization by Semi-Supervised Learning of Apparent Flow.ĬardiacSegmentationPropagation is a Python-based tool for cardiac image segmentation. ![]() ![]() ![]() Using deep learning, the method is both fast and lightweight. CardiacMotionFlow is a Python-based tool for 2D cardiac MRI registration (or apparent flow generation), cardiac motion extraction, and cardiac pathology classification. ![]() There are a number of methods for balancing chemical equations. ![]() In case of ionic reactions, the same electric charge must be present on both sides of the equation. Thus, each side of the equation must represent the same quantity of atoms of any chemical element. It’s important because in a chemical reaction, the quantity of each element does not change (the law of conservation of mass). This means looking for stoichiometric coefficients for the reactants and products. So, the first step in chemical reaction calculations is balancing chemical equations. Our Chemical Reaction Calculator implements the above algorithm and helps you solve most chemical problems in seconds without resorting to time-consuming calculations. When solving chemical calculation problems using reaction equations, the following algorithm can be used:ġ) Write an equation for a chemical reaction and balance it.Ģ) Convert the problem data (mass, volume) to the amount of substance (moles).ģ) Find the amounts of reaction products according to the coefficients in the reaction equation.Ĥ) Convert the found amounts of substances into mass (volume) according to the condition of the problem. This means that the ratio of the amounts of reactants (in moles) is equal to the ratio of the corresponding coefficients in the reaction equation. Substances enter into chemical reactions in quantities proportional to the coefficients in the chemical equation. The chemical reaction equation shows which substances react with each other and in what quantities, as well as what substances are formed and how much of each can be obtained. The field with the limiting reactant is highlighted in pink. In addition, the amounts of unreacted reagents are calculated and the limiting reactant is determined. If you enter in the corresponding fields the amounts of reagents, either as number of moles or weight in grams, then, after pressing the ‘Enter’ key, you will get the amounts of reaction products (in moles and grams). To calculate the amount of reagents you need to take to get a certain amount of a given reaction product, enter that amount either as the number of moles or as its weight in grams in the corresponding field and then press the ‘Enter’ key. In case the original equation was unbalanced, the field with this equation is highlighted in light pink. ![]() In what follows is a more detailed syntax guide to our calculator.Īfter you click the ‘Calculate’ button, the equation is automatically balanced and a list of all reactants and reaction products involved in the chemical reaction appears. ) or the asterisk (*) precedes the water formula (e.g. ![]() H₂O) which then automatically converted to normal form. H 2O) or with the help of the ‘tiny’ numbers, like ₂ or ₅, (e.g. The indices are denoted using and html tags (e.g. You can enter a chemical equation manually or paste the equation copied from a web page or text document (including DOC or PDF file). The chemical reaction equation may include free electrons and electrically charged molecules (ions) as well as hydrated compounds. In addition, the amount of unreacted reagents and the limiting reactant are determined. It also calculates the amounts of reactants and reaction products in both moles and grams. This online Chemical Reaction Calculator checks whether a given chemical equation is balanced and finds the appropriate stoichiometric coefficients. ![]() They asked us if we’d all be interested in coming up to Bellevue and doing that there and we said yes. Both sides spoke about our values and how, when you get right down to it, we, as human beings, are hard-limited by the time we have left when it comes to making the things we care about and believe in. Third, and last, we had a series of long conversations with the people at Valve and everyone shared the satisfaction we take in working with people whose talents dwarf our own to make things we never thought possible. So in some sense, this is a return home for us. Never ones to pass up free alcohol, we stole it and drank it to celebrate the launch of Firewatch a year later. It happened to be engraved on an unopened bottle of champagne. Second, while visiting IGN’s headquarters in early 2015 to talk about Firewatch, we came across an undelivered 2011 Game of the Year Award for Portal 2. In us, they found a group with unique experience and valuable, diverse perspectives. In Valve we found a group of folks who, to their core, feel the same way about the work that they do (this, you may be surprised to learn, doesn’t happen every day). ![]() From the day-to-day production of our last game, Firewatch, to the way we run the company, make merchandise, meet players at expos and shows, send out a quarterly literary journal, throw open-to-the-public game demos in the middle of an artificial forest-all of it is geared towards surprising, delighting, and entertaining the customers who have shared in our success. Furthermore, and perhaps more accurately, we really like making and producing entertainment. First, we really like making video games. If you’re the type of person who gives two flips about this news, we can elaborate a little bit on this big decision. SAN FRANCISCO–LOS ANGELES–LONDON–SOMEWHERE IN NORTHERN ENGLAND-The twelve of us at Campo Santo have agreed to join Valve, where we will maintain our jobs as video game developers and continue production on our current project, In the Valley of Gods. Just head outside and see what speaks to you. First place will have their pick of the three, second will have their pick of the remaining two and third place will get whichever print is left.Īnd when we say “in the wild” that can be whatever that means to you! You don’t need to climb a mountain or take a trip to Wyoming to make something special. We’ll pick our favorites on January 2nd and get in touch with you via DM. Now that you can take Firewatch with you wherever you go, if you capture a picture or small video of Firewatch being played in the wild and post it to Twitter or Instagram, tag us and/or use the tag #firewatchswitch you’ll be automatically entered to win one of three of the exceptionally out-of-print-never-to-be-sold-again Olly Moss Firewatch screen prints we released in 2015. Last week, we launched Firewatch for the Nintendo Switch and to commemorate that launch (and as a nod to the amazing live-action trailer Derek Lieu put together for us) we’re doing a little giveaway. Finally, we summarize the current state of RIPK1 inhibitors in the clinic, including disease indications, small-molecule chemotypes, as well as RIPK1 target engagement and pharmacodynamic biomarkers. We postulate that the improved understanding of genetic and mechanistic data may be beneficial in segmenting patients in clinical trials, particularly for neurodegenerative and inflammatory diseases. The involvement of RIPK1 in sepsis and acute ischaemic conditions is also discussed. In this Review, we outline the current understanding of RIPK1 biology in activating cell death and NF-κB signalling, systematically review monogenic and polygenic variants of known RIPK1 regulators and discuss how these mutations may contribute to disease pathology. The important role of RIPK1 in driving cell death and inflammation, the established safety of inhibiting RIPK1 kinase activity in humans and the ability to develop selective small-molecule kinase inhibitors of RIPK1 due to the presence of a unique kinase-regulating allosteric pocket are the major factors that have contributed to RIPK1’s prominence as a therapeutic target. These trials have laid the groundwork for advancing clinical applications of RIPK1 inhibitors. The brain-penetrant DNL747 is in human clinical trial phase Ib/IIa for amyotrophic lateral sclerosis (ALS) 15, 16. The peripherally restricted GSK′772 is being developed for peripheral autoimmune diseases, including psoriasis, rheumatoid arthritis (RA) and ulcerative colitis 12, 13, 14. Broad therapeutic applications of RIPK1 inhibitors for the treatment of a wide range of human diseases are being investigated in clinical trials. Necrostatin-1s (Nec-1s) was the first small-molecule inhibitor of RIPK1 kinase to be developed and has been widely used to investigate the role of RIPK1 in mechanistic studies and animal models of human diseases 1, 8, 9, 10, 11. However, as researchers continued to delve into the mechanisms governed by RIPK1, it has become apparent that RIPK1 inhibitors may offer key therapeutic options that anti-TNF therapies do not: first, RIPK1 inhibitors are safe in the central nervous system (CNS) as RIPK1 kinase does not signal through TNFR2 which has a protective role in the CNS 7 second, RIPK1 participates in a broader set of pro-inflammatory activities than those restricted to TNF 8 third, RIPK1 is regulated by a distinct set of signalling molecules that are genetically implicated in human autoimmune and autoinflammatory diseases, as discussed below, and thus patient stratification may be important in conducting clinical trials of RIPK1 inhibitors. ![]() As TNFR1-mediated RIPK1 activation is the most comprehensively characterized paradigm, RIPK1 inhibitors were originally considered to primarily offer a small-molecule alternative to anti- TNF antibody therapies for TNF-driven autoimmune conditions. RIPK1 kinase activation has been demonstrated in post-mortem human pathological samples of autoimmune and neurodegenerative conditions 3, 4, 5, 6, and inhibition of RIPK1 kinase activity has shown efficacy in a wide range of animal models of human diseases. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a master regulator of the cellular decision between pro-survival NF-κB signalling and death in response to a broad set of inflammatory and pro-death stimuli in human diseases 1, 2. Equilateral triangleĪn equilateral triangle has all three sides equal, and all three interior angles equal, too. In the diagram above, the length of side AB = AC and ∠ ABC =∠ ACB. Equal lengths of a triangle are shown by making an arc on each side. We can classify triangles into 3 types based on the lengths of their sides:Īn isosceles triangle is a triangle in which two sides and two angles are equal. Classification of triangles according to the length of their sides In the illustration above, angle a = 90 degrees while angles b and c are acute angles. The hypotenuse is the side of a right triangle with the longest length. Right TriangleĪ right triangle is a triangle in which one of the angles is exactly 90 degrees. Obtuse triangleĪn obtuse triangle is a triangle in which one of the interior angles is more than 90 degrees.Īngle a is more obtuse, while angles b and c are acute. The types of triangles are classified based on:Ĭlassification of triangles according to the measure of interior anglesĪccording to the measure of interior angles, we can classify triangles into three categories:Īn acute angle triangle is a triangle in which all three interior angles are less than 90 degrees.Įach one of the angles a, b and c is less than 90 degrees. We use the symbol ∆ to denote a triangle. It is a polygon with three corners, three vertices, and three angles joined together that forms a closed diagram. What is a Triangle?Ī triangle is a two-dimensional closed figure with 3 sides. This article will discuss the meaning of a triangle, the different types of triangles and their properties, and their real-life applications. Eratosthenes (276 BC – 195 BC), again, used the same method to determine the distance around the surface of Earth (called circumference). ![]() Miletus (624 BC – 547 BC), a Greek mathematician, adopted Egypt’s geometry and was brought to Greece.Īristarchus (310 BC – 250 BC), a Greek mathematician, used the above method to find the distance between the Earth and the Moon. ![]() It is a perfectly engineered model that its lengths and angles on all sides are the same. Its shape is actually that of a 3D pyramid, which has triangular faces. The Egyptians created the pyramids around 2900 B.C. Then they used to apply the law of sines for calculating the required distance. They measure the distance from two different locations, then measure the angle created by shift or parallax, formed by the observer’s movement between the two locations. ![]() The word triangle is taken from the Latin word ‘triangulus,’ which means three-cornered.ĭuring ancient times, astronomers had created a method called triangulation to determine the distances of the distant stars. In simple words, a triangle is a polygon with 3 sides. In Geometry, a triangle is the most important shape, defined as a closed two-dimensional diagram containing 3 sides, 3 angles, and 3 vertices. Types of Triangles – Explanation & Examples In 2014, PayPal opened a new global center of operations in Kuala Lumpur. PayPal is using the following colors for their brand. In 2011, joining similar customer support operations located in Berlin, Germany Chandler, Arizona Dublin and Dundalk, Ireland Omaha, Nebraska and Shanghai, China PayPal opened a second customer support center in Kuala Lumpur, Malaysia, and began the hiring process. The upper limit on the export size is 5000 x 5000px for bitmap images. In October 2007, PayPal opened a data service office on the north side of Austin, Texas, and also opened a second operations center in La Vista, Nebraska that same year. PayPal opened a technology center in Scottsdale, Arizona in 2006, and a software development center in Chennai, India in 2007. West Bangal, India - Ap: PayPal logo on phone screen stock image. The PayPal European headquarters are located in Luxembourg and the international headquarters are in Singapore. You can now download for free this Paypal Logo transparent PNG image. Since July 2007, PayPal has operated across the European Union as a Luxembourg-based bank. The company's operations center is located in Omaha, Nebraska, which was opened in 1999. PayPal's corporate headquarters are located in the North San Jose Innovation District of San Jose, California, at North First Street campus. The company ranked 204th on the 2019 Fortune 500 of the largest United States corporations by revenue. Our logos and banners are a great way to reassure your customers that you choose PayPal to process payments securely. In 2015, eBay spun off PayPal to eBay's shareholders. PayPal logos, graphics and buttons at your fingertips. Get unlimited downloads on all our 110K templates You can make a logo, video, mockup, flyer, business card and social media image in seconds right from. It became a wholly owned subsidiary of eBay later that year, valued at $1.5 billion. It charges a fee in exchange for benefits such as one-click transactions and password memory.Įstablished in 1998 as Confinity, PayPal had its initial public offering in 2002. The company operates as a payment processor for online vendors, auction sites, and many other commercial users. The PayPal logo images, icons and vectors below can be used widely to advertise that you accept PayPal purchases (which itself supports Visa. It means that you can use and modify it for. is an American company operating an online payments system in the majority of countries that support online money transfers, and serves as an electronic alternative to traditional paper methods like checks and money orders. mohamed mahmoud hassan has released this Paypal, Logo, Brand, Pay, Payment image under Public Domain license. |